The Dynamics of the Dengue Fever Virus and the Creation of its Vaccine

The Dynamics of the breakbone fever Fever Virus and the Creation of its VaccineAbstractI investigated Dengue Fever and the dynamics of creating a drug or vaccine tocure it. After acquiring a basic knowledge of the virus I genus Columba into various topicsincluding variants on the virus such as Dengue Shock Syndrome and DengueHemorrhagic Fever. Then I looked into the molecular structure of the diseases proteinsand how their shape relates to how it can be selled by drugs. Professor Tantilloslectures about drug design, including pharmacokinetics, pharmacodynamics and ADMET(Absorption, Distribution, Metabolism, Excretion, Toxicity) connected the concepts ofprotein molecular structure and effective ways to treat diseases. After researching thebasic history behind Dengue Fever, I came to the conclusion that Dengue Fever is anextremely prominent disease that has no cure and impart be very difficult to cure in thefuture due to our lack of knowledge about it.A nine-year-old boy in Campos d os Goytacazes, and urban region of Rio deJaneiro, was admitted into a hospital displaying a fever in excess of 103 degrees. He wastreated for his symptoms but there was no official diagnosis 6. A day later he wasdischarged from the hospital, yet returned two days later with a worsening condition andelevated levels of his previous symptoms. On the ordinal day he was diagnosed withDengue Fever Shock Syndrome (a derivative of Dengue Fever). Eventually his conditionspiraled into anemia, heart murmurs, and gastritis. Dengue Fever (DF) is a knownFlavivirus 2, which move into the same family of viruses such as Yellow fever,Hepatitis C, West Nile Virus and about fifty other viruses 4. DF is found in such placesas Central/Sou... ...222-2225 25 July 20085 Schlesinger, R. W. Dengue Viruses. Wien Springer-Verlag, 1977.6 SOUZA, Luiz Jos de, CARNEIRO, Helder Gonalves, SOUTO FILHO, Joo TadeuDamian et al. Hepatitis in Dengue Shock Syndrome. Braz J Infect Dis online. 2002, vol.6, no. 6 citado 200 8-07-29, pp. 322-327. Disponvel em86702002000600010&lng=pt&nrm=iso. ISSN 1413-8670. doi 10.1590/S1413-867020020006000107 Tantillo. (Lectures 23 July 2008 and 25 July 2008)8 Whitehead, Steven S., Joseph E. Blaney, Anna P. Durbin, and Brian R. Murphy.Prospects for a Dengue Virus Vaccine. Nature Reviews 5 (2007) 518-28. 25 July 20089 Xinhua. Thailand to test Mahidol-developed dengue vaccine prototype. PeoplesDaily Online 05 Sept. 2005.